Autonomic Dysfunction in Rett Syndrome

• Agitation

• Dyspraxia

• Slow responsiveness

• Disorganised breathing

• Vasomotor changes (blue hands and feet)

• Vacant spells

• “Sudden Infant Death” like syndrome

• Gastro-esophageal reflux

• Pupillary dilation

• Constipation 90%

• Abdominal distention (bloating) 50%

• Occasional urinary retention

• Panic like attacks

• Fluctuating mood

• Sleep disturbances

• Labile BP and HR